Integrative Multi-Omics’ methods
We use computational methods to integrate simultaneous gene expression and chromatin accessibility data from single-cell and bulk assays. Our approach consists of deploying genome-wide analyses to identify cell-specific regulatory signatures. Our current data sets capture time-cours studies to investigate cell differentiation processes during immune response to malaria infection from murine models and humans.
dEPIMAL Project aims to study the relationship between antigenic stimulus upon Plasmodium infection or re-infection and gene regulation of immune cells during pre-immunisation. Our goal is understanding the chromatin remodelling and heterogeneity of immune cell linages and states upon parasite exposures in splenic and peripheral blood mononuclear cells. Differences at exposure during this immune-protective process indicates specific epigenetic states of immune cells have a key role in the development of an effective natural immunity.
Immunoproteomics of Pf-specific antigens
We develop immunoproteomic methods to characterise antigen repertoires from individual serums with differential protective response to malaria. The identification of P. falciparum immunoglobulins (i.e. IgM and IgG) antigenic variability in individuals by immunoproteomic-wide analysis will improve association studies of regulatory landscapes of immune cells.
Selected publications
